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In var c body e h if return setTimeout q . tps science article pii and archaea possess range of defense mechanisms to combat plasmids viral infections. inJournals InHelp Download Issues January Pages and Applications of CRISPR Systems Harnessing Nature Toolbox for Genome links open overlay panelAddison . P a. sj evt re BNCHCLoaded for void u var in return rt function tualr y if . fel function for var rf null div return gc if document s h yle

Sj evt re BNCHCLoaded for void u var in return rt function tualr y if . write b ose catch f p d. rights and contentUnder Elsevier user licenseopen archiveBacteria archaea possess range of defense mechanisms to combat plasmids viral infections. tagName return while rentNode sj sp pointerdown Skip to main content Please note that Internet Explorer version. ns f lay if t function e var new Date h ift sj evt nd sched sb st wpc Inst mplete . fel function for var rf null div return gc if document s h yle. display block n t if return LowerCase dexOf chromn chrdef mozsbr mozlbr moztsb sj evt nd onP var function ue . P a. end u. In this Review we discuss recent advances understanding the diverse mechanisms by which Cas proteins respond to foreign nucleic acids how these systems have been harnessed precision genome manipulation wide array of article issueNext articlesCiting Copyright Elsevier Inc. js var customData if window geData usabilla live. Unique among these are CRISPRCas clustered regularly interspaced short palindromic repeatsCRISPR associated systems which provide adaptive immunity against foreign nucleic acids. x is not supported as of January . CRISPR systems function by acquiring genetic records of invaders to facilitate robust interference upon reinfection