MeOB. eyceaikyi and merabered. Foll jag the procedure in Example were prepared . H i q Hz [...]

W ter nL. I bmm. potassium etSrvipropaa otaie and substituted alky feaiides [...]

Ajpyridia yi ofl. TFA and solvent B ACN with onn gradient fro to . Mass spectrum apci x [...]

Assays were conducted at SC using controlled ahsorbance plate reader Speetrarnax PC Molecular Devices Corp. mtnal la ml of DCM at under akreger was added CP. f. Mass spectrum apd z [...]

S aikyi asaiao aninosyJfoByL. w ter nL [...]

The resulting mixture was extracted with EtOAc ml pooled extracts were washed water rut arid brine dried anhydrous sodium sulfate and concentrated. Mass ecSiriHi EST. The eiher was iheii washed with water and brine then dried filtered Sttd eortcestfaied. The crude was directly purified by reversephase preparative HPLC sing [...]

X ihydro yridi sy cftytea . iX dd . was ai ed aad heated again atttiiltix ovenrfg Ilse reaction cooled dikiied wish water rat and sfeed vigot oasly [...]

L dlmgthyli Hra ytS. ay H S [...]

J d. iBoe piperidia yi ioxo py. H t Hz [...]

L pyf dyl met o. I H d [...]

FtiHOl were gilded and this was sparged for another tnin before reaetio healed to flC oae cmspk period. enyI io repbetiyh dicMoroph s dkMrophe yL ch. me yl z lo b pyrtdm Sy [...]

Mmol were added and the et irwas warmed to with stirring over Reaction placed back OS see feath thm . yibaiyI trifluoro sifeyl feydroxyebyi ftydraxybaiyl ydrxy mefby asyk hydmxy n Siiy p syi rhydi meftiyihexyi metboxypropyt. Exam le B [...]