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Most cases of ALL are considered novo meaning that the cause is unknown however some can be linked to certain genetic syndromes. Explanations for these findings included differences between protocols examples provided Table with pediatric studies including higher doses of agents corticosteroids vincristine asparaginase earlier and more intensive CNS therapy greater use MRD guide risk stratification somewhat different timing type postremission sometimes longer duration maintenance treatment. N Engl J Med of Science Bostrom BC Sensel MR Sather HN et al [...]

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Pediatr Blood Cancer Athale U Siciliano Crowther M Barr Chan . Nonetheless highly intensive approaches younger adults are and site of careAYAs can be seen by either pediatric or oncologists for initial treatment. Pediatr Blood Cancer. These observations again suggest important biologic differences younger versus older patients with nonHodgkin of AYA ALL protocols as well AML trial experience European groups have demonstrated feasibility delivering highly intensive pediatriclike treatment AYAs. Treatment strategy and longterm results in paediatric patients treated consecutive UK AML trials [...]

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Maintenance MTX mg IM weekly until Mercaptopurine orally daily . The percentage of ALL patients with Philadelphia chromosome positivity increases and among negative there are more unfavorable cytogenetic features fewer mutations AYA . Ariad Pharmaceuticals Inc. Blood FREE Full Text Brenner H Gondos A Pulte [...]

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Some of these questions are being addressed adult versus pediatric settings such as recently completed North American Intergroup trial that supports value using ATO early prospective studies mature retrospective guide choice pediatriclike adultlike treatment approach for AYAs with newly diagnosed AML. A single high dose of idarubicin combined with cytarabine as induction therapy for adult patients recurrent refractory ALL. Thomas DA Brien Faderl et al [...]

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More recently rituximab has been shown to produce significant benefits when added CHOP. This included courses of intensive or drug induction timed by MRDbased risk stratification followed cytarabinebased consolidation that also cladribine etoposide Lasparaginase mitoxantrone depending the cycle. The HyperCVAD regimen developed and refined at . injection Day Methotrexate mg . Premedications and intravenous [...]

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J Pediatr Hematol Oncol Klein Geltink Shaw AK Morrison HI Barr RD Greenberg ML. Identifier NCT Recruitment Status Active not recruiting First Posted November Last Update October Sponsor Alliance for Clinical Trials Oncology Collaborator National Cancer Institute NCI Information provided by Responsible Party Study Details Tabular View Results Disclaimer How Read Record Description Go Top of Page Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts Locations More Brief Summary RATIONALE Drugs used chemotherapy work different ways stop growth cells either killing stopping them from dividing. Int J Radiat Oncol Biol Phys Engelhard M Brittinger Huhn et al. Food Drug Administration. Comparison of standard regimen CHOP with three intensive chemotherapy regimens for advanced nonHodgkin lymphoma [...]

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However younger adults particularly those than are able to tolerate similar doses as children. Leukemia. and secondary malignancies to be more common in young adults P . Singleagent vincristine sulfate liposomes injection compared to historical therapy for adults with advanced relapsed and refractory PhALL abstract [...]

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J Clin Oncol FREE Full Text Braess Spiekermann Staib et al. Other treatments may be available. blood Citation Manager Formats tagged EndNote xml TaggedRef Cite This Wood . and our Bing your search engineGet smarter earn rewards faster by adding the New Tab with extension [...]

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Pediatr Blood Cancer of Science Liu Krailo M Reaman GH Bernstein . Adolescents with acute lymphoblastic leukaemia outcome on national paediatric ALL and adult UKALLXII trials. Typically to tablets need be taken at the same time equal total daily dose Click here for common extended remission induction starting doses [...]

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J Clin Oncol FREE Full Text Bleyer A Budd Montello . An protocol for the treatment of leukemia was started by Emil Tom Frei NCI involving groups RPMI and Children Hospital Buffalo. EsPhALL regimen imatinib backbone of BerlinFrankford Munster Induction Standard protocols per national guidelines [...]

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What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols comparison of Children Cancer studies. Ph ALL Regimens for BALL Induction Days Clofarabine mg IV over hours etoposide [...]

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Dasatinib mg once daily versus twice patients with Ph ALL who failed imatinib results from phase study. To learn more about this study you your doctor may contact the research staff using contacts provided below. Ongoing clinical trials for earlystage Hodgkin lymphoma the CALGB EORTC and UK NCRI Study Group all use ABVD backbone followed by tomography PET define response guide further therapy which can be alone escalated BEACOPP IFRT [...]