Usual care No prompts guidelines. EGDT vs. RSBI was very sensitive index but not specific. JAMA Early vs Late Tracheotomy for Prevention of Pneumonia in Mechanically Ventilated Adult ICU Patients days [...]

Crit Care Med Noninvasive Ventilation to Prevent Respiratory Failure after Extubation Highrisk Patients Multicenter randomized controlled study requiring hours mechanical of postextubation hypercapnia CHF ineffective cough excessive secretions more than one weaning trial comorbid condition upper airway obstruction. RR hospital mortality . S [...]

Outcome Inhospital mortality. CAVEATS Openlabel no placebo. CI [...]

FACTT study Fluid and Catheter Treatment Trial. Specificity was. hr run in period Differences from past trials Proning was done EARLY hours after randomization vigorously least consecutive [...]

Chest Association between Reduced Cuff Leak Volume and Postextubation Stridor consecutive intubations subsequent extubations measured the difference inspiratory tidal averaged expiratory over breaths while was deflated. NIPPV for hours vs. conventional ventilation HFOV mortality vs [...]

Propofol vs. days Control patients had usual care and study hospitals were encouraged to use ARDSnet protocols unclear whether they did or what fraction of didn get . deaths respectively. JAMA LOV Lung Open Ventilation trial pts [...]

Therefore may use combination hydrocort Fludrocort to treat relative adrenal insufficiency. Brochard et al. placebo x days with taper [...]

Patients who die faster tend to only get PRBCs while those don FFP platelets. Specificity was. Pseudomonas infections had higher recurrence after day treatment . points respectively CI for difference . Adults within hours had known or presumed infection at least SIRS criteria AND either refractory hypotension SBP despite IVF lactate mmol Assigned early goal directed therapy EGDT for vs [...]

Rescue Strategies Sud et al. Cooling was begun the field Hypothermia after Cardiac Arrest Study Group. sedation per usual care with SBT [...]

Late Trach for article on vent weaning through tracheostomy. Asfar et al. ARISE Trial [...]

CAVEATS Openlabel no placebo. Note that previous trials showed higher PEEP helps but these were performed before all patients on low lung volume protective ventilation [...]

It probably is but that was NOT tested and different hypothesis requires noninferiority trial equivalence . NICESUGAR NEJM Intensive vs [...]