Rights and contentUnder Elsevier user licenseopen The DEMETER computational model segregates onfrom offtarget effects RNAi strong differential dependencies were identified in cancer cell lines Predictive models for found using molecular features This dependency map facilitates prioritization therapeutic human epithelial tumors harbor numerous alterations making difficult to which genes are required survival. length f o sb ie return if function a var ge hps sj ce span url default homepage endChild try catch isHomepage http main cook SRCHS PC padding px margin . We demonstrated the basis behind one such predictive model linking of UBB ubiquitin gene to dependency UBC. pricing Sulfadiazine VETRANAL analytical standard [...]

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We further show that expanded CMap can be used to discover mechanism of action small molecules functionally annotate genetic variants disease genes inform clinical trials. rights and contentUnder Elsevier user licenseopen The DEMETER computational model segregates onfrom offtarget effects RNAi strong differential dependencies were identified in cancer cell lines Predictive models for found using molecular features This dependency map facilitates prioritization therapeutic human epithelial tumors harbor numerous alterations making difficult to which genes are required survival [...]